MovDisordV3, France, Analysis, bibRecord, 000501

Somatosensory disinhibition in dystonia

Identifieur interne : 000501 ( France/Analysis ); précédent : 000500; suivant : 000502

Somatosensory disinhibition in dystonia

Auteurs : Emma Frasson [Italie] ; Alberto Priori [Italie] ; Laura Bertolasi [Italie] ; Francois Mauguière [France] ; Antonio Fiaschi [Italie] ; Michele Tinazzi [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2001-07.

RBID : ISTEX:E0941C5106E2E0B09507D76E8F291750C93241BE

Descripteurs français

Pascal (Inist)
- Dystonie, Homme, Physiopathologie, Potentiel évoqué somatosensoriel.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Brain Stem (physiopathology), Dystonia, Dystonia (physiopathology), Electric Stimulation, Evoked Potentials, Somatosensory (physiology), Feedback (physiology), Female, Frontal Lobe (physiopathology), Human, Humans, Male, Median Nerve (physiopathology), Middle Aged, Motor Neurons (physiology), Neural Inhibition (physiology), Parietal Lobe (physiopathology), Pathophysiology, Somatosensory evoked potential, Spinal Cord (physiopathology), dystonia, paired stimulation, recovery cycle, somatosensory evoked potentials, somatosensory system, upper limb SEPs.
MESH :
- physiology : Evoked Potentials, Somatosensory, Feedback, Motor Neurons, Neural Inhibition.
- physiopathology : Brain Stem, Dystonia, Frontal Lobe, Median Nerve, Parietal Lobe, Spinal Cord.
- Adult, Electric Stimulation, Female, Humans, Male, Middle Aged.

Abstract

Despite the fact that somatosensory processing is inherently dependent on inhibitory functions, only excitatory aspects of the somatosensory feedback have so far been assessed in dystonic patients. We studied the recovery functions of spinal N13, brainstem P14, parietal N20, P27, and frontal N30 somatosensory evoked potentials (SEPs) after paired median nerve stimulation in 10 patients with dystonia and in 10 normal subjects. The recovery functions were assessed (conditioning stimulus: S1; test stimulus: S2) at interstimuls intervals (ISIs) of 5, 20, and 40 ms. SEPs evoked by S2 were calculated by subtracting the SEPs of the S1 only response from the SEPs of the response to the paired stimuli (S1 + S2), and their amplitudes were compared with those of the control response (S1) at each ISI considered. This ratio, (S2/S1)*100, investigates changes in the excitability of the somatosensory system. No significant difference was found in SEP amplitudes for single stimulus (S1) between dystonic patients and normal subjects. The (S2/S1)*100 ratio at the ISI of 5 ms did not significantly differ between dystonic patients and normal subjects, but at ISIs of 20 and 40 ms, this ratio was significantly higher in patients than in normals for spinal N13 and cortical N20, P27, N30 SEPs. These findings suggest that in dystonia there is an impaired inhibition at spinal and cortical levels of the somatosensory system which would lead to an abnormal sensory assistance to the ongoing motor programs, ultimately resulting in the motor abnormalities present in this disease. © 2001 Movement Disorder Society.

Url:

https://api.istex.fr/document/E0941C5106E2E0B09507D76E8F291750C93241BE/fulltext/pdf

DOI: 10.1002/mds.1142

Affiliations:

France, Italie
Lyon

Links to Exploration step

ISTEX:E0941C5106E2E0B09507D76E8F291750C93241BE

Le document en format XML

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<term>Evoked Potentials, Somatosensory (physiology)</term>
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<front><div type="abstract" xml:lang="en">Despite the fact that somatosensory processing is inherently dependent on inhibitory functions, only excitatory aspects of the somatosensory feedback have so far been assessed in dystonic patients. We studied the recovery functions of spinal N13, brainstem P14, parietal N20, P27, and frontal N30 somatosensory evoked potentials (SEPs) after paired median nerve stimulation in 10 patients with dystonia and in 10 normal subjects. The recovery functions were assessed (conditioning stimulus: S1; test stimulus: S2) at interstimuls intervals (ISIs) of 5, 20, and 40 ms. SEPs evoked by S2 were calculated by subtracting the SEPs of the S1 only response from the SEPs of the response to the paired stimuli (S1 + S2), and their amplitudes were compared with those of the control response (S1) at each ISI considered. This ratio, (S2/S1)*100, investigates changes in the excitability of the somatosensory system. No significant difference was found in SEP amplitudes for single stimulus (S1) between dystonic patients and normal subjects. The (S2/S1)*100 ratio at the ISI of 5 ms did not significantly differ between dystonic patients and normal subjects, but at ISIs of 20 and 40 ms, this ratio was significantly higher in patients than in normals for spinal N13 and cortical N20, P27, N30 SEPs. These findings suggest that in dystonia there is an impaired inhibition at spinal and cortical levels of the somatosensory system which would lead to an abnormal sensory assistance to the ongoing motor programs, ultimately resulting in the motor abnormalities present in this disease. © 2001 Movement Disorder Society.</div>
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Movement Disorders (revue)

Somatosensory disinhibition in dystonia

Somatosensory disinhibition in dystonia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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